A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

About the study

The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.

Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Inclusion Criteria:

Have a history of axial-predominant low back pain
Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs
Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening
Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight

EXCLUSION CRITERIA

Exclusion Criteria:

Have a non-axial origin low back pain
Have had botulinum or steroid injections to the spine within 1 year of screening
Have had trigger point injection to the spine within 6 months of screening
Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90 days prior to screening
Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening
Have a prior or planned surgical treatment for obesity
Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes